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What Is the Endocannabinoid System? An Evergreen Guide Last updated: April 22, 2026 · By Steve Schultheis, Founder — Steve's Goods The endocannabinoid system — ECS for short — is one of the body's internal signaling networks. It was discovered in the 1990s during research into how THC produces its effects, and it has since been recognized as a broad regulatory system that the body uses to keep many of its own processes in balance. This guide describes the ECS as researchers currently unde