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What is CBD isolate? What is CBD isolate? CBD isolate is an extract of the major cannabinoid found in hemp that can be up to 22% CBD. When we extract the CBD from the hemp we are collecting only the rich plant material and getting rid of the waste material (this is where the THC hangs out once extracted from hemp). Once it is extracted, it is processed through winterization and decarboxylating. When all is said and done, it is ready for isolation. What does CBD isolate affect? A better quest