As CBD gains popularity, you may be wondering if it can work for you. There’s a good chance it can, but there are things you need to know if you’re taking pharmaceuticals as part of your health plan. CBD changes the way your body responds to certain medications, so be sure to do your research and work with knowledgeable professionals.
What is Pharmacokinetics?
The branch of pharmacology concerned with how drugs move through the body is called Pharmacokinetics. Pharmacokinetics studies the timelines of absorption, bioavailability, distribution, metabolism, and excretion looking at every method of ingestion— inhalation, oral, oral-mucosal or sublingual, topical or rectal.
The study of pharmacokinetics is fascinating. There are things you may not have thought of that change the way your body receives pharmaceuticals, based on the drug. They include grapefruit, alcohol, foods high in vitamin K, dairy products, and more.
CBD Drug Interactions Can Stem From a Change in Absorption Rates
In an NIH study on interactions between Warfarin and CBD, scientists found CBD to be metabolized by way of the hepatic CYP450 enzyme system.
In layman’s terms, this means that when consumed with certain medications, CBD can affect the amount of the drug absorbed by your liver into your system. The effect can go in either direction, more or less.
There have been absorption related CBD interactions with other drugs besides Warfarin, too. It depends on how the body metabolizes the drug.
CYP Enzymes and Drugs
Studies from the Department of Health reveal that CBD is a potent inhibitor of CYP3A4 and CYP2D6.
CYP enzymes control the speed that drugs are broken down, and the length of time they stay in your system.
“As CYP3A4 metabolizes about a quarter of all drugs, CBD may increase serum concentrations of macrolides, calcium channel blockers, benzodiazepines, cyclosporine, sildenafil (and other PDE5 inhibitors), antihistamines, haloperidol, antiretrovirals, and some statins (atorvastatin and simvastatin, but not pravastatin or rosuvastatin).
“CYP2D6 metabolizes many antidepressants, so CBD may increase serum concentrations of SSRIs, tricyclic antidepressants, antipsychotics, beta-blockers and opioids (including codeine and oxycodone).”
CBD Interactions Studies
Drugs processed by the above mentioned CYP enzymes need adept supervision when CBD is added to the mix. Doses are prescribed based on how the enzymes metabolize the drugs; different absorption rates can wreak havoc on your system, especially with psychotropics, opioids, and blood thinners.
Pharmaceuticals drugs of concern include but are not limited to:
- omeprazole (Prilosec, Omesec)
- clozapine (Clozaril, FazaClo)
- progesterone (Prometrium, others)
- lansoprazole (Prevacid)
- flutamide (Eulexin)
- oxaliplatin (Eloxatin)
- erlotinib (Tarceva)
- ketamine (Ketalar)
- orphenadrine (Norflex)
- secobarbital (Seconal)
- dexamethasone (Decadron)
Any drug that is changed by certain enzymes in the liver.
That’s why it’s vital to work with your physician. They will help you titrate both changes; coming off the pharmaceuticals and adding the CBD by tracking your progress through bloodwork and observation. You’ll want to pay close attention to both subtle and noticeable changes in your body and keep your doctor in the loop.
What Are The Side Effects of CBD?
It’s good to know that according to the World Health Organization, “In humans, CBD exhibits no effects indicative of any abuse or dependence potential…. To date, there is no evidence of public health-related problems associated with the use of pure CBD.”
While CBD is safe to use, too much of any good thing, is usually not so good. That’s why finding out the best dose for your needs is worth the time.
Side effects usually stem from not taking the correct dose or interactions with prescription medications. If you’re this far into the article, you already know our advice about prescription medications and working with someone who can make sure you’re regulated. If you’re not on medications, check out our CBD dosing chart for how we recommend getting started.
Side effects vary depending on the method of CBD ingestion and the person involved
- dry mouth
- lower blood pressure
Some people don’t experience them, and some do.
In fact, the NIH did a study of a cross-section of cannabis users and published the following results: “Almost 62% of CBD users reported using CBD to treat a medical condition. The top three medical conditions were pain, anxiety, and depression. Almost 36% of respondents reported that CBD treats their medical condition(s) “very well by itself,” while only 4.3% reported, “not very well.” One out of every three users reported a non-serious adverse effect. The odds of using CBD to treat a medical condition were 1.44 (95% confidence interval, 1.16–1.79) times greater among non-regular users of cannabis than among regular users.”
What You Should Know Before Taking CBD Period
We meet many people in our travels who have misconceptions about hemp, cannabis, CBD, and THC. That’s why our first platform is hemp education.
Here are a few things that usually need clearing up. While they both come from the cannabis family of plants, hemp and marijuana are very different. Here’s how.
Marijuana plants have higher percentages of THC. THC is psychoactive and gets you high. On the other hand, hemp plants have higher concentrations of non-psychoactive CBD. Processed according to law with less than .3% THC, it won’t get you lit, but it can get you well.
It matters where you buy your CBD for so many reasons. One of the most important — if you try an inferior product that doesn’t work for you, you may be turned off to something that could ultimately be beneficial.
That’s why we make the following recommendations again and again.
When purchasing CBD know your source and your source’s source.
- Where do they get their raw materials?
- How do they process them?
- Do they provide COA’s on every batch?
- Is the product compliant to federal standards of .3% THC?
- Is it pure and potent?
We hear over and over that we’re the best. We don’t mind telling you we enjoy that feedback, mainly because it means our products are making a difference. We’d love for you to taste our wares. There are many reputable companies out there selling good products with your best interest in mind. We know you have a choice.
Steve’s Goods CBD has conscience from seed to sale. We’re here to help you understand the ins, outs, and benefits of using cannabinoids to bring your system towards and into balance.
Reach out with any questions. We look forward to speaking with you. Please remember, we do not give medical advice.